LONG MU QING XIN MIXTURE IMPROVES BEHAVIORAL PERFORMANCE IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR/NCRL) BY UPREGULATING CATECHOLAMINE NEUROTRANSMITTERS IN PREFRONTAL CORTEX AND STRIATUM VIA DRD1/CAMP/PKA-CREB SIGNALING PATHWAY

BackgroundAttention deficit hyperactivity disorder (ADHD), a Horse First-Aid prevalent neurodevelopmental disorder in children, can be effectively alleviated by the herbal preparation Long Mu Qing Xin Mixture (LMQXM), but its mechanism has not been fully elucidated.ObjectiveTo scrutinize the potential pharmacological mechanisms by which LMQXM impro

Abstract Background Consideration of tissue-specific gene expression in reconstruction and analysis of molecular genetic networks is necessary for a proper description of the processes occurring in a specified tissue.Currently, there are a number of computer systems that allow the user to reconstruct molecular-genetic networks using the data automa

A technology for the automatic multi-class labeling of brain electron microscopy (EM) objects needed to create large synthetic datasets, which could be used for brain cell segmentation tasks, is proposed.The main research tools were a generative diffusion AI model and a U-Net-like segmentation model.The technology was studied on the segmentation ta

Liver fibrosis represents the consequences of a sustained wound healing response to chronic liver injuries, and its progression Rice Cooker toward cirrhosis is the major cause of liver-related morbidity and mortality worldwide.However, anti-fibrotic treatment remains an unconquered area for drug development.Accumulating evidence indicate that oxida

Microglia originate from myeloid progenitors in the embryonic yolk sac and play INFLAMMEX an integral role in central nervous system (CNS) development, immune surveillance and repair.The role of microglia in multiple sclerosis (MS) has been complex and controversial, with evidence suggesting that these cells play key roles in both active inflammati